Studying platinum sensitivity and resistance in high-grade serous ovarian cancer: different models for different questions

High-grade serous ovarian cancer (HGSOC) has the highest mortality rate among all gynecological cancers. Patients are generally diagnosed in an advanced stage with the majority of cases displaying platinum resistant relapses. Recent genomic interrogation of large numbers of HGSOC patient samples indicated high complexity in terms of genetic aberrations, intra- and intertumor heterogeneity and underscored their lack of targetable oncogenic mutations. Sub-classifications of HGSOC based on expression profiles, termed ‘differentiated’, ‘immunoreactive’, ‘mesenchymal’ and ‘proliferative’, were shown to have prognostic value.

Source: Drug Resistance Updates - November 26, 2015 Category: Drugs & Pharmacology Authors: Nicolette G. Alkema, G. Bea A. Wisman, Ate G.J. van der Zee, Marcel A.T.M. van Vugt, Steven de Jong Source Type: research