BMPs in Bone Regeneration: Less is more effective, a paradigm-shift

In 1889, N. Senn reported that decalcified bone induced healing in bone defects with osteomyelitis [1]. G. Levander demonstrated in a series of studies starting in 1934 that bone extract injected into muscles caused ectopic bone formation [2–4]. In 1945, P. Lacroix reported a substance he called “osteogenin”, which he had extracted from the cartilaginous epiphysis of the long bones of newly born rabbits. He subsequently injected the osteogenin into the thigh muscles of other rabbits and induced the formation of an osteoma, revealing the presence of all the structures of a growing long bone [5].

Source: Cytokine and Growth Factor Reviews - November 25, 2015 Category: Molecular Biology Authors: Katharina Schmidt-Bleek, Bettina M. Willie, Philipp Schwabe, Petra Seemann, Georg N. Duda Tags: Mini review Source Type: research