Structural insights into BMP receptors: specificity, activation and inhibition

Members of the transforming growth factor-β (TGFβ) superfamily are secreted multi-functional growth factors that determine the development, maintenance and regeneration of tissues and organs. Their importance in the development of multicellular organisms is clear from their presence in all vertebrates and invertebrate animals. On the basis of their phylogenetic and functional relationships, the TGFβ/BMPs can be subdivided into four subgroups, which also highlight mechanistic differences in receptor binding and activation or the differences found in modulatory mechanisms.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Survey Source Type: research