Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet

Conclusions:
In obesity-resistant mice, peripubertal HFD is sufficient to irreversibly promote carcinogen-induced tumorigenesis. Increased macrophage recruitment is likely a contributing factor. These results underscore the importance of early life exposures to increased adult cancer risk and are consistent with findings that an HFD in normal weight premenopausal women leads to increased breast cancer risk. Notably, short-latency tumors occurring after peripubertal HFD had characteristics similar to human basal-like breast cancers that predominantly develop in younger women.

Source: Breast Cancer Research - November 2, 2015 Category: Cancer & Oncology Authors: Mark AupperleeYong ZhaoYing TanYirong ZhuIngeborg LangohrErin KirkJason PironeMelissa TroesterRichard SchwartzSandra Haslam Source Type: research