Soluble receptor for advanced glycation end-products and aortic stiffness in general population

It has been suggested that accumulation of advanced glycation end-products (AGE) is involved in several pathophysiological processes in the vessel wall. Soluble isoform of receptor for AGE (sRAGE) acts as a decoy for capturing circulating AGE, prevents them from binding to the cell-surface receptor and protects against the RAGE-AGE axis-elicited processes. We hypothesized that low sRAGE levels might be associated with increased arterial stiffness.

Source: Artery Research - November 24, 2015 Category: Cardiology Authors: Otto Mayer, Jan Filipovsky, Jitka Seidlerova, Petra Karnosova, Peter Wohlfahrt, Renata Cifkova, Jindra Windrichova, Ondrej Topolcan Source Type: research