A new dynamic organ bath setup to assess isobaric stiffness parameters of periodically stretched isolated mouse aortic segments

Cyclic stretch is a major contributor of vascular function. However, isolated mouse aortas are frequently studied at low stretch frequency or even isometric conditions. Pacing experiments done in rodents and humans show that arterial compliance is highly cyclic stretch frequency-dependent. The Rodent Oscillatory Tension Set-up to study Arterial Compliance (ROTSAC) is an in-house developed organ bath that clamps aortic segments (width 2mm, diameter 0.5-3mm) to imposed preloads at physiological rates up to 600bpm.

Source: Artery Research - November 24, 2015 Category: Cardiology Authors: Arthur J.A. Leloup, Cor E. Van Hove, Guido R.Y. De Meyer, Dorien M. Schrijvers, Gilles W. De Keulenaer, Paul Fransen Source Type: research