Platelet-localized FXI promotes a glycoprotein Ibα dependent feedback loop in arterial hypertension and vascular inflammation

Background: Interactions of platelets, leukocytes and the vessel wall play pivotal roles in activating coagulation and precipitating thrombosis. High levels of angiotensin II (ATII) cause arterial hypertension by a complex inflammatory pathway requiring leukocyte recruitment and reactive oxygen species production within the vessel wall.

Source: Artery Research - November 24, 2015 Category: Cardiology Authors: Jeremy Lagrange, Sabine Kossmann, Moritz Ehlken, Brett Monia, Wolfram Ruf, Philip Wenzel Source Type: research