In idiopathic pulmonary arterial hypertension arterial narrowing is limited and heterogeneous

Rationale: In severe idiopathic pulmonary arterial hypertension, iPAH, pulmonary vascular resistance is increased due to remodeling of the small (resistance) arteries. Most information on arterial remodeling is limited to assessments of averaged increases in wall thickness. Quantitative information on the number of arteries affected and their internal diameter decrease in relation to vessel size is limited. Our objective was therefore to quantify numbers of affected small arteries and their internal diameter decrease for the differently sized vessels.

Source: Artery Research - November 24, 2015 Category: Cardiology Authors: Nina Rol, Esther Timmer, Theo Faes, Harm Jan Bogaard, Anton Vonk Noordegraaf, Katrien Grünberg, Nico Westerhof Source Type: research