Conditional inactivation of integrin av subunit in vascular smooth muscle cells regulates fibrosis in vessels

Integrin avb3 is expressed at high density in vascular smooth muscle cells (VSMCs). It functions as a receptor for adhesion proteins in VSMCs which phenotypic modulation plays a pivotal role in arteriosclerosis and atherosclerosis.

Source: Artery Research - November 24, 2015 Category: Cardiology Authors: Ekaterina Belozertseva, Melusine Didelot, Amel Mohamadi, Zhenlin Li, Huguette Louis, Jean-Baptiste Michel, Véronique Regnault, Patrick Lacolley Source Type: research