Potential of Ginger (Zingiber officinale) Rhizome and Watermelon (Citrullus lanatus) Seeds in Mitigating Aspartame-Induced Oxidative Stress in Rat Model

Aspartame (ASP) consumption has been reported to implicate oxidative stress and antioxidant supplements from plant origin are one of the safest ways of averting their effect in the body. The current study was aimed at ascertaining the ability of aspartame (ASP) to induce oxidative stress in rats as well as assessing the potential of ginger (Zingiber officinale) rhizome and watermelon (Citrullus lanatus) seeds extracts in averting the aspartame induced oxidative stress. This was done using sperm parameters and biochemical assays such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase, melonaldehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase and alkaline phosphate (ALP). Forty eight sexually matured male albino rats were divided into six groups (A-F) with eight rats in each group. Group A served as the positive control and received physiological saline. Group B served as the negative control and were administered with 1000 mg kg–1 b.wt., of aspartame (ASP). Rats in group C were administered with 1000 mg kg–1 b.wt., ASP+500 mg kg–1 b.wt., of ginger extracts while rats in group D were administered with 1000 ASP+1000 mg kg–1 b.wt., of ginger extracts. On the other hand, rats in group E received 1000 mg kg–1 b.wt., ASP+500 mg kg–1 b.wt., of watermelon seed extracts while rats in group F received 1000 mg kg–1 b.wt., ASP+1000 mg kg–1 b.wt., of watermelon seed extracts. The result revealed that administr...
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research