A phase II trial to evaluate single-dose stereotactic body radiation therapy (SBRT) prior to surgery for early-stage breast carcinoma: SIGNAL (stereotactic image-guided neoadjuvant ablative radiation then lumpectomy) trial

This study will assess the toxicity associated with using a single preoperative dose of radiation as a replacement for standard adjuvant radiotherapy in breast-conserving therapy. Results of this trial will guide the design of a possible phase III study. Trial registration: Clinicaltrials.gov identifier: NCT02212860
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research