Nanoparticle dosage—a nontrivial task of utmost importance for quantitative nanosafety research

For a detailed and correct understanding of effects of colloidal nanoparticles exposed to organisms, a correlation of such effects to the physicochemical properties of the nanoparticles is a necessity. Such correlation is complex by the fact that many physicochemical parameters such as size, shape, surface charge, and colloidal stability are interlinked, and nontrivial to experimentally determine. This review aims to give an overview regarding such correlations. Particular focus will be given on the role of determining nanoparticle concentrations, which is the basis for most quantitative toxicity evaluations. A comparison of mass versus particle number concentrations is given, and their respective differences are highlighted. For further resources related to this article, please visit the WIREs website.
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - Category: Nanotechnology Authors: Tags: Advanced Review Source Type: research