Silver nanoparticles and electroporation: Their combinational effect on Leishmania major

In this study, after applying electric pulses with different concentrations of silver nanoparticles (SNPs), cell survival rate was determined by standard viability assays. On the basis of these data, 2 μg/ml of SNPs and 700 V/cm with 100 μs duration of electroporation were selected as the non‐lethal condition. Promastigotes and infected macrophage cells received both treatments and the survival percentage and Infection Index were calculated. In parasites and cells receiving both treatments, higher toxicity was observed in comparison to each treatment given individually, showing a synergic effect on promastigotes. Therefore, application of electric pulses could overcome limitations in using the antileishmanial properties of silver nanoparticles. Bioelectromagnetics. © 2015 Wiley Periodicals, Inc.
Source: Bioelectromagnetics - Category: Radiology Authors: Tags: Research Article Source Type: research