Prolonged hyperinsulinemia affects metabolic signal transduction markers in a tissue specific manner

Insulin dysregulation is common in horses, although the mechanisms of metabolic dysfunction are poorly understood. We hypothesized that insulin signaling in striated (cardiac and skeletal) muscle and lamellae may be mediated through different receptors as a result of receptor content, and that transcriptional regulation of downstream signal transduction and glucose transport may also differ between tissues sites during hyperinsulinemia. Archived samples from horses treated with a prolonged insulin infusion or a balanced electrolyte solution were used.

Source: Domestic Animal Endocrinology - November 18, 2015 Category: Endocrinology Authors: A. Campolo, M.A. de Laat, L. Keith, K.J. Gruntmeir, V.A. Lacombe Source Type: research