Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin

In this study, we demonstrated that the anti-human CCR4 immunotoxin bound and depleted monkey CCR4+ cells in vitro.

Source: Molecular Oncology - November 19, 2015 Category: Cancer & Oncology Authors: Zhaohui Wang, Shannon G. Pratts, Huiping Zhang, Philip J. Spencer, Ruichao Yu, Makoto Tonsho, Jigesh A. Shah, Tatsu Tanabe, Harrison R. Powell, Christene A. Huang, Joren C. Madsen, David H. Sachs, Zhirui Wang Source Type: research