Development of affinity-based delivery of NGF from a chondroitin sulfate biomaterial.

We describe the use of both chondroitin sulfate and a novel chondroitin sulfate-binding peptide to control the release of nerve growth factor. Interestingly, the novel chondroitin sulfate-binding peptide enhances the controlled release properties of the chondroitin sulfate gels. While introduction of chondroitin sulfate into a scaffold inhibits primary cortical outgrowth, the combination of chondroitin sulfate, chondroitin sulfate-binding peptide and nerve growth factor promotes primary cortical neurite outgrowth in chondroitin sulfate gels.
PMID: 23507746 [PubMed - indexed for MEDLINE]

Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research