Magnetic force microscopy: quantitative issues in biomaterials.

Magnetic force microscopy: quantitative issues in biomaterials. Biomatter. 2014;4 Authors: Passeri D, Dong C, Reggente M, Angeloni L, Barteri M, Scaramuzzo FA, De Angelis F, Marinelli F, Antonelli F, Rinaldi F, Marianecci C, Carafa M, Sorbo A, Sordi D, Arends IW, Rossi M Abstract Magnetic force microscopy (MFM) is an atomic force microscopy (AFM) based technique in which an AFM tip with a magnetic coating is used to probe local magnetic fields with the typical AFM spatial resolution, thus allowing one to acquire images reflecting the local magnetic properties of the samples at the nanoscale. Being a well established tool for the characterization of magnetic recording media, superconductors and magnetic nanomaterials, MFM is finding constantly increasing application in the study of magnetic properties of materials and systems of biological and biomedical interest. After reviewing these latter applications, three case studies are presented in which MFM is used to characterize: (i) magnetoferritin synthesized using apoferritin as molecular reactor; (ii) magnetic nanoparticles loaded niosomes to be used as nanocarriers for drug delivery; (iii) leukemic cells labeled using folic acid-coated core-shell superparamagnetic nanoparticles in order to exploit the presence of folate receptors on the cell membrane surface. In these examples, MFM data are quantitatively analyzed evidencing the limits of the simple analytical models currently used. ...
Source: Biomatter - Category: Biotechnology Tags: Biomatter Source Type: research