Mouse models of human bladder cancer as a tool for drug discovery.

Mouse models of human bladder cancer as a tool for drug discovery. Curr Protoc Pharmacol. 2010 Jun;Chapter 14:Unit14.14 Authors: Seager C, Puzio-Kuter AM, Cordon-Cardo C, McKiernan J, Abate-Shen C Abstract Muscle-invasive bladder cancer is a deadly condition in dire need of effective new treatments. This unit contains a description of mouse models suitable for the evaluation of potential new therapies. Included is a genetically engineered mouse model of bladder cancer generated by the delivery of an adenovirus expressing Cre recombinase into the bladder lumen. Also described is an orthotopic mouse model created by the instillation of human bladder tumor cells into the bladder lumen of immune deficient mice. Protocols are also provided on the use of these models for the preclinical evaluation of new chemical entities, with mTOR inhibitors shown as an example. PMID: 22294368 [PubMed - indexed for MEDLINE]
Source: Current Protocols in Pharmacology - Category: Drugs & Pharmacology Tags: Curr Protoc Pharmacol Source Type: research