Intrinsic subtypes and genomic signatures of primary breast cancer and prognosis after systemic relapse

Molecular subtypes and gene expression signatures are widely used in early breast cancer but their role in metastatic disease is less explored. Two hundred-twenty patients diagnosed with primary breast cancer and subsequent relapse in Stockholm, Sweden between 1997-2006 were identified and their primary tumor was assessed for immunohistochemistry (IHC)- and PAM50-based subtypes, risk of recurrence (ROR-S) score, 21-gene and 70-gene signatures using research-based microarray expression profiles.Clinical and pathological data were retrospectively collected.

Source: Molecular Oncology - November 17, 2015 Category: Cancer & Oncology Authors: Claudette Falato, Nicholas P. Tobin, Julie Lorent, Linda S. Lindström, Jonas Bergh, Theodoros Foukakis Source Type: research