Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure

Conclusions: HF alters the response of ICa,L to Ang-(1-7). In normal myocytes, Ang-(1-7) has no significant effect on ICa,L. However, in HF myocytes, Ang-(1-7) increases ICa,L. These effects are mediated by the Ang-(1-7) Mas receptors and involve activation of NO/BK pathways.

http://tak.sagepub.com/cgi/content/abstract/9/6/342?rss=1

Source: Therapeutic Advances in Cardiovascular Disease - November 16, 2015 Category: Cardiology Authors: Zhou, P., Cheng, C. P., Li, T., Ferrario, C. M., Cheng, H.-J. Tags: Original Research Source Type: research