Risk Stratification in Women with Gestational Diabetes According to and Beyond Current WHO Criteria.

Risk Stratification in Women with Gestational Diabetes According to and Beyond Current WHO Criteria.
Horm Metab Res. 2015 Nov 13;
Authors: Much D, Jaschinski H, Lack N, Hummel S, Füchtenbusch M, Hummel M, Ziegler AG, Beyerlein A
Abstract
The pregnancy outcomes in women with gestational diabetes mellitus (GDM) and 'overt diabetes in pregnancy' were compared and the need for further subclassification was investigated with respect to postpartum outcome risk. Data from 944 women who had been uniformly diagnosed as having GDM in Munich, Germany, between 1998 and 2010, were re-classified into GDM and 'overt diabetes in pregnancy'. Pregnancy related outcomes in the offspring were derived from Bavarian birth registry data. Classification and regression trees were used to identify further GDM sub-phenotypes. In total, 88 women (9.3%) were re-classified as having 'overt diabetes in pregnancy'. Compared to women with GDM, women with 'overt diabetes in pregnancy' used insulin more frequently, and were at increased risk for large for gestational age infants [odds ratio 2.50 (95% confidence interval 1.02, 6.13)], preterm delivery [odds ratio 3.28 (1.02, 10.50)], and low APGAR-score at 5 min [odds ratio 12.70 (1.58, 102.2)]. In the 856 women with GDM, classification and regression tree analyses provided further risk stratification in that a combination of fasting glucose>5.3 mmol/l and 1-h glucose>11.1 mmol/l at GDM diagnosis predicted...

Source: Diabetes Metab - November 13, 2015 Category: Endocrinology Authors: Much D, Jaschinski H, Lack N, Hummel S, Füchtenbusch M, Hummel M, Ziegler AG, Beyerlein A Tags: Horm Metab Res Source Type: research