Clinical Trial Participants With Metastatic Renal Cell Carcinoma Differ From Patients Treated in Real-World Practice [Original Contributions]

Conclusion:
Patients with mRCC treated with tyrosine kinase inhibitors in real-world clinical practice are sicker than those enrolled onto pivotal clinical trials, and more than one third are trial ineligible. Application of clinical trial findings to dissimilar populations may result in patient harm. Clinical research with more inclusive eligibility criteria is needed to appropriately guide real-world practice.

Source: Journal of Oncology Practice - November 13, 2015 Category: Cancer & Oncology Authors: Mitchell, A. P., Harrison, M. R., Walker, M. S., George, D. J., Abernethy, A. P., Hirsch, B. R. Tags: Methodology, Systemic Therapy, Clinical Trials Original Contributions Source Type: research