Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: repertoire of somatic genetic alterations and clonal relationships

Lobular carcinoma in situ (LCIS) has been proposed as a non-obligate precursor of invasive lobular carcinoma (ILC). Here we sought to define the repertoire of somatic genetic alterations in pure LCIS and in synchronous LCIS and ILC using targeted massively parallel sequencing.

Source: Molecular Oncology - November 13, 2015 Category: Cancer & Oncology Authors: Rita A. Sakr, Michail Schizas, Jose Victor S. Carniello, Charlotte K.Y. Ng, Salvatore Piscuoglio, Dilip Giri, Victor P. Andrade, Marina De Brot, Raymond S. Lim, Russell Towers, Britta Weigelt, Jorge S. Reis-Filho, Tari A. King Source Type: research