Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration

Conclusions:
Together, these results demonstrate that TRPA1 expression via activation of p38 MAPK in DRG neurons, at least in part, contributes to the development of oxaliplatin-induced acute cold hyperalgesia.

Source: Molecular Pain - November 13, 2015 Category: Molecular Biology Authors: Ken YamamotoNoriko ChibaTerumasa ChibaToshie KambeKenji AbeKazuyoshi KawakamiIku UtsunomiyaKyoji Taguchi Source Type: research