Heart failure: a complex clinical process interpreted by systems biology approach and network medicine.

Heart failure: a complex clinical process interpreted by systems biology approach and network medicine.
Anadolu Kardiyol Derg. 2014 Feb 11;
Authors: Louridas GE, Lourida KG
Abstract
Systems biology is founded on the principles of integrative computational analysis and on the data from genetic and molecular components. The integration of biological components produces interacting networks, modules and phenotypes with remarkable applications in the field of clinical medicine. The evolving concept of network medicine gives a more precise picture of the intrinsic complexity of failing myocardium and its clinical consequences. The present review is focused on the impact of network cardiology in explaining the progressive nature of the clinical syndrome of heart failure. The failing myocardium and the subsequent clinical syndrome of heart failure disclose a dynamical and non-linear system with a progressive picture of clinical deterioration. The classical description of heart failure is based on tissue pathology and clinical presentation, and lately on specific genetic and molecular modifications. This characterization of heart failure has significant limitations to recognize preclinical disease features and to explain the progressive nature of the syndrome. Systems biology detects and evaluates specific networks from molecular, cellular and tissue elements, and assesses their influence on the appearance of clinical phenotypes. The classical reducti...

Source: The Anatolian Journal of Cardiology - February 11, 2014 Category: Cardiology Authors: Louridas GE, Lourida KG Tags: Anadolu Kardiyol Derg Source Type: research