Myostatin inhibits porcine intramuscular preadipocyte differentiation in vitro

This study assessed the effect of myostatin on adipogenesis by porcine intramuscular preadipocytes. Intramuscular preadipocytes were isolated from the longissimus dorsi muscle of newborn pigs. Myostatin inhibited intramuscular preadipocyte differentiation in a dose-dependent manner. Myostatin treatment during preadipocyte differentiation significantly (P < 0.05) inhibited the expression of the adipogenic marker genes CCAAT/enhancer-binding protein β, CCAAT/enhancer-binding protein α, peroxisome proliferator-activated receptor γ, sterol regulatory element–binding protein-1c, fatty acid–binding protein, and adiponectin.

Source: Domestic Animal Endocrinology - October 30, 2015 Category: Endocrinology Authors: W.X. Sun, M.V. Dodson, Z.H. Jiang, S.G. Yu, W.W. Chu, J. Chen Source Type: research