Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum

ConclusionsOur results demonstrate for the first time expression of SIRT2–3 and SIRT5–7 in the human CC. Aged individuals with CVDRF presented an increase in SIRT7 protein levels and a decrease in mitochondrial SIRT3. This finding suggests that CVDRF induces the loss of antioxidant defense mechanisms leading to endothelial injury. Freitas M, Rodrigues AR, Tomada N, Fonseca J, Magalhães A, Gouveia AM, Neves D. Effects of aging and cardiovascular disease risk factors on the expression of sirtuins in the human corpus cavernosum. J Sex Med **;**:**–**.

Source: The Journal of Sexual Medicine - November 9, 2015 Category: Sexual Medicine Authors: Margarida Freitas, Adriana R. Rodrigues, Nuno Tomada, João Fonseca, Alexandre Magalhães, Alexandra M. Gouveia, Delminda Neves Tags: Original Research Source Type: research