Pericyte Antigens in Perivascular Soft Tissue Tumors

Discussion. In summary, pericyte marker expression is a ubiquitous finding in glomus tumor, myopericytoma, and angioleiomyoma. Malignant glomus tumor shows a comparative reduction in pericyte marker expression, which may represent partial loss of pericytic differentiation. Pericyte markers are essentially not seen in solitary fibrous tumor. The combination of αSMA, CD146, and PDGFRβ immunohistochemical stainings may be of utility for the evaluation of pericytic differentiation in soft tissue tumors.

Source: International Journal of Surgical Pathology - November 9, 2015 Category: Pathology Authors: Shen, J., Shrestha, S., Yen, Y.-H., Asatrian, G., Mravic, M., Soo, C., Ting, K., Dry, S. M., Peault, B., James, A. W. Tags: Original Articles Source Type: research