GPCR profiling: from hits to leads and from genotype to phenotype

This article focuses on GPCR platform strategies from hits to leads with miniaturized complex pharmacology approaches. Three main areas of GPCR profiling are discussed including pharmacologically relevant hit identification, the pharmacology dossier applied to parallel structure activity and structure liability relationships and high-throughput mechanism studies from genotype to phenotype.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research