Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice.

CONCLUSIONS: Taken together, a short-term, high-fat diet augments denervation muscle atrophy by induction of protein degradation in the mitochondria-rich soleus but not in the glycolytic EDL. These findings suggest that the denervation-induced loss of mitochondria and HF diet-induced impairment of mitochondrial function may combine to promote skeletal muscle atrophy. PMID: 26539241 [PubMed]

http://www.ncbi.nlm.nih.gov/pubmed/26539241?dopt=Abstract

Source: Diabetes Metab - November 7, 2015 Category: Endocrinology Authors: Roseno SL, Davis PR, Bollinger LM, Powell JJ, Witczak CA, Brault JJ Tags: Nutr Metab (Lond) Source Type: research