CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway

CBP (CREB-binding protein) is a transcriptional co-activator which possesses HAT (histone acetyltransferace) activity and participates in many biological processes, including embryonic development, growth control and homeostasis. However, its roles and the underlying mechanisms in the regulation of carcinogenesis and tumor development remain largely unknown. Here we investigated the molecular mechanisms and potential targets of CBP involved in tumor growth and survival in lung cancer cells. Elevated expression of CBP was detected in lung cancer cells and tumor tissues compared to the normal lung cells and tissues.

Source: Molecular Oncology - November 5, 2015 Category: Cancer & Oncology Authors: Zhipeng Tang, Wendan Yu, Shilei Zhao, Yao Xiao, Zhenlong Yu, Canhui Yi, Ranran Tang, Yang Xuan, Wenjing Yang, Jiaojiao Hao, Tingting Xu, Qianyi Zhang, Wenlin Huang, Wuguo Deng, Wei Guo Source Type: research