Genome-wide DNA methylation analyses in lung adenocarcinomas: association with , and mutation status, gene expression and prognosis

DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells. Lung cancer patients have in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed.

Source: Molecular Oncology - November 5, 2015 Category: Cancer & Oncology Authors: Maria Moksnes Bjaanæs, Thomas Fleischer, Ann Rita Halvorsen, Antoine Daunay, Florence Busato, Steinar Solberg, Lars Jørgensen, Elin Kurea, Hege Edvardsena, Anne-Lise Børresen-Dale, Odd Terje Brustugun, Jörg Tost, Vessela Kristensen, Åslaug Helland Source Type: research