Pimobendan effects on arrhythmias in small breed dogs

Pimobendan is an arteriodilator, venodilator, and positive inotrope. Its action is classified as an inodilator and is exerted via inhibition of phosphodiesterase III and calcium sensitization. Pimobendan has beneficial effects in dogs with congestive heart failure (CHF) due to myxomatous mitral valve degeneration (MMVD). Early clinical trials of pimobendan in humans demonstrated an increased incidence of arrhythmia-related sudden death, which led the FDA to deny the drug a license for human use.
Source: Advances in Small Animal Medicine and Surgery - Category: Veterinary Research Tags: Cardiology Source Type: research