Point-of-care anticoagulant rodenticide test for dogs

Anticoagulant rodenticide toxicosis is one of the most common intoxications in small animals and is a major cause of poison-related morbidity and mortality. Anticoagulant rodenticides are widely used in rodent control. These compounds inhibit hepatic vitamin K1 epoxide reductase, thereby reducing synthesis of functional vitamin K1-dependent clotting factors (factors II, VII, IX, X) by preventing carboxylation of glutamate and formation of gamma-carboxyglutamate (Gla) residues. Formation of Gla domains is essential for functional vitamin K1-dependent clotting factors.
Source: Advances in Small Animal Medicine and Surgery - Category: Veterinary Research Tags: Clinical Pathology Source Type: research