Facteurs pronostiques des carcinomes lobulaires infiltrants du sein : à propos de 940 cas

Conclusion L’analyse de cette série de 940 CLI de stade T1 et T2 apporte plusieurs informations : les facteurs associés à l’atteinte des ganglions lymphatiques axillaires sont l’âge de moins de 65ans, la taille de la tumeur de plus de 20mm et un grade SBR 2 ou 3. Les mêmes facteurs sont significativement corrélés aux taux de SSR et de SG. L’envahissement macrométastatique des ganglions axillaires a un impact significatif sur la SSR et la SG, contrairement aux pNi+ et aux pNmic, qui semblent avoir le même pronostic que les pN0. Objectives To assess the prognostic factors of T1 and T2 infiltrating lobular breast cancers, and to investigate predictive factors of axillary lymph node involvement. Methods This is a retrospective multicentric study, conducted from 1999 to 2008, among 13 french centers. All data concerning patients with breast cancer who underwent a primary surgical treatment including a sentinel lymph node procedure have been collected (tumors was stage T1 or T2). Patients underwent partial or radical mastectomy. Axillary lymph node dissection was done systematically (at the time of sentinel procedure evaluation), or in case of sentinel lymph node involvement. Among all the 8100 patients, 940 cases of lobular infiltrating tumors were extracted. Univariate analysis was done to identify significant prognosis factors, and then a Cox regression was applied. Analysis interested factors that improved disease free survival, overall survival ...
Source: Gynecologie Obstetrique and Fertilite - Category: OBGYN Source Type: research