Chimeric antigen receptor T cell therapy: 25years in the making

Chimeric antigen receptor (CAR) T cell therapy of cancer is generating enormous enthusiasm. Twenty five years after the concept was first proposed, major advances in molecular biology, virology and good manufacturing practices (GMP)-grade cell production have transformed antibody-T cell chimeras from a scientific curiosity to a fact of life for academic cellular immunotherapy researchers and increasingly, for patients. In this review we explain the preclinical concept, outline how it has been translated to the clinic and draw lessons from the first years of CAR T cell therapy for the practicing clinician.

Source: Blood Reviews - November 5, 2015 Category: Hematology Authors: Saar Gill, Marcela V. Maus, David L. Porter Tags: REVIEW Source Type: research