Cytotoxic Activities of Eosinophil Cationic Protein and Eosinophil-derived Neurotoxin: In Silico Analysis

Conclusion: The greater cationicity of ECP may be related to its higher cytotoxicity and to the fact that the varying post-translational modification profiles can generate functional differences from structural alteration. In vivo and in vitro studies need to be performed in order to confirm these predictions.

Source: Cancer Genomics and Proteomics - November 5, 2015 Category: Cancer & Oncology Authors: DE OLIVEIRA, P. C. R., DE OLIVEIRA LOPES, D., DO VALE COELHO, I. E., PEREIRA, M. C. Tags: Article Source Type: research