Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma

Periampullary adenocarcinomas can be of two histological subtypes, intestinal or pancreatobiliary. The latter is more frequent and aggressive, and characterized by a prominent desmoplastic stroma, which is tightly related to the biology of the cancer, including its poor response to chemotherapy. Whereas miRNAs are known to regulate various cellular processes and interactions between cells, their exact role in periampullary carcinoma remains to be characterized, especially with respect to the prominent stromal component of pancreatobiliary type cancers.

Source: Molecular Oncology - November 2, 2015 Category: Cancer & Oncology Authors: V. Sandhu, IM Bowitz Lothe, K.J. Labori, M.L. Skrede, J. Hamfjord, A.M. Dalsgaard, T. Buanes, G. Dube, M.M. Kale, S. Sawant, U. Kulkarni-Kale, A.-L. Børresen-Dale, O.C. Lingjærde, E.H. Kure Source Type: research