FSH-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes

The effect of follicle-stimulating hormone (FSH) on apoptotic status of cumulus cells, expression of pro- and anti-apoptotic genes and development rate of IVF produced buffalo embryos was investigated. FSH supplementation in in vitro maturation (IVM) medium resulted in a dose-dependent reduction in the expression of pro-apoptotic genes namely, BCL2 associated X protein (BAX), cytochrome c and caspase-3 and increase in the expression of anti-apoptotic genes like B-cell lymphoma 2 (BCL2) and X-linked Inhibitor of apoptosis protein (XIAP) in cumulus cells of mature oocyte.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research