The protective action of the aqueous extract of auricularia polytricha in paracetamol induced hepatotoxicity in rats.

THE PROTECTIVE ACTION OF THE AQUEOUS EXTRACT OF AURICULARIA POLYTRICHA IN PARACETAMOL INDUCED HEPATOTOXICITY IN RATS. Recent Pat Drug Deliv Formul. 2015 Oct 30; Authors: Chellappan DK, Ganasen S, Batumalai S, Candasamy M, Krishnappa P, Dua K, Chellian J, Gupta G Abstract Natural antioxidant products are increasingly being used to treat various pathological liver injuries considering the role of oxidative stress in their pathogenesis. Auricularia polytricha been put to use as food or medicine due to its antioxidant activity. The aim of the study was to evaluate the protective effect of the aqueous extract of the fruiting bodies of A. polytricha against paracetamol-induced liver toxicity in rats. Liver toxicity was induced in Sprague-Dawley rats by oral administration of 2g/kg paracetamol on the 15th day after the administration of aqueous extract and silymarin 100 mg/kg. Aqueous extract of A. polytricha were administered orally at 250 and 500 mg/kg doses, daily for a period of 14 days. Aspartate aminotransferase (AST), Alanine transaminase (ALT) and Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH), Total bilirubin (TB), Total protein (TP), Triglycerides (TG) and cholesterol were measured to assess the effect of the extract on paracetamol-induced hepatic damage. The study also included histopathological examination of liver sections to assess hepatoprotective activity. Paracetamol significantly (P<0.001) increased the serum A...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research