Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: novel strategies to overcome cancer chemoresistance

Our current understanding of the mechanisms of action of antitumor agents and the precise mechanisms underlying drug resistance is that these two processes are directly linked. Moreover, it is often possible to delineate chemosresistance mechanisms based on the specific mechanism of action of a given anticancer drug. A more holistic approach to the chemoresistance problem suggests that entire metabolic pathways, rather than single enzyme targets may better explain and educate us about the complexity of the cellular responses upon cytotoxic drug administration.

Source: Drug Resistance Updates - October 31, 2015 Category: Drugs & Pharmacology Authors: Laura Taddia, Domenico D’Arca, Stefania Ferrari, Chiara Marraccini, Leda Severi, Glauco Ponterini, Yahuda G. Assaraf, Gaetano Marverti, Maria Paola Costi Source Type: research