The influence of Insulin-like Growth Factor-1-Receptor expression and endocrine treatment on clinical outcome of postmenopausal hormone receptor positive breast cancer patients: A Dutch TEAM substudy analysis

Signaling via the Insulin-like Growth Factor type 1 Receptor (IGF1R) plays a crucial role in cancer development. In breast cancer (BC), IGF1R and estrogen receptor expression are correlated. In this current study we explored the hypothesis that postmenopausal hormone receptor positive (HR+ve) BC patients with high IGF1R tumor expression still have estrogen driven IGF1R stimulated tumor growth when treated with tamoxifen, resulting in detrimental clinical outcome compared to patients treated with exemestane.

Source: Molecular Oncology - October 31, 2015 Category: Cancer & Oncology Authors: Charla C. Engels, Nienke A. de Glas, Anita Sajet, Esther Bastiaannet, Vincent THBM. Smit, Peter JK. Kuppen, Caroline Seynaeve, Cornelis JH. van de Velde, Gerrit Jan Liefers Source Type: research