Alpha-melanocyte stimulating hormone inhibits monocytes adhesion to vascular endothelium

In this study, the effects of α-melanocyte stimulating hormone on endothelial inflammation in human umbilical vein endothelial cell lines were investigated. And the result indicated that α-melanocyte stimulating hormone inhibits the expression of endothelial adhesion molecules, including vascular adhesion molecule-1 and E-selectin, thereby attenuating the adhesion of THP-1 cells to the surface of endothelial cells. Mechanistically, α-melanocyte stimulating hormone was found to inhibit NF-B transcriptional activity. Finally, we found that the effect of α-melanocyte stimulating hormone on endothelial inflammation is dependent on its receptor melanocortin receptor 1.

Source: Experimental Biology and Medicine - October 30, 2015 Category: Research Authors: Yang, Y., Zhang, W., Meng, L., Yu, H., Lu, N., Fu, G., Zheng, Y. Tags: Pharmacology/Toxicology Source Type: research