CAR T-cell immunotherapy: The path from the by-road to the freeway?

Chimeric antigen receptors are genetically encoded artificial fusion molecules that can re-program the specificity of peripheral blood polyclonal T-cells against a selected cell surface target. Unparallelled clinical efficacy has recently been demonstrated using this approach to treat patients with refractory B-cell malignancy. However, the approach is technically challenging and can elicit severe toxicity in patients. Moreover, solid tumours have largely proven refractory to this approach. In this review, we describe the important structural features of CARs and how this may influence function.

Source: Molecular Oncology - October 22, 2015 Category: Cancer & Oncology Authors: Lynsey M. Whilding, John Maher Tags: Review Source Type: research