Oxidative DNA damage is associated with inflammatory response, insulin resistance and microvascular complications in type 2 diabetes

Publication date: Available online 20 October 2015 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Etiane Tatsch, José A.M.De Carvalho, Bruna S. Hausen, Yãnaí S. Bollick, Vanessa D. Torbitz, Thiago Duarte, Rogério Scolari, Marta M.M.F. Duarte, Sílvia W.K. Londero, Rodrigo A. Vaucher, Melissa O. Premaor, Fabio V. Comim, Rafael N. Moresco Urinary markers of nucleic acid oxidation may be useful biomarkers in diabetes. It hasbeen demonstrated that T2DM patients have an increased level of oxidative DNA damage; however, it is unclear whether increased DNA damage may be related to a greater degree of inflammation and insulin resistance. Thus, the aim of this present study was to investigate the relation of the impact of oxidative DNA damage, assessed by urinary 8-OHdG, on the levels of inflammatory cytokines, as well as insulin resistance. In addition, we also investigated the diagnostic ability of urinary 8-OHdG in the identification of microvascular complications in T2DM.A case-control study, enrolling 22 healthy controls and 54 subjects with T2DM, was performed to evaluate the relation between oxidative DNA damage and interleukin-6 (IL-6), IL-1,tumor necrosis factor-alpha (TNF-α), IL-10, and Homeostasis Model Assessment (HOMA-IR) index. T2DM patients presented higher urinary 8-OHdG, IL-6, IL-1, TNF-α levels and HOMA-IR, and lower IL-10 levels than control subjects.Moreover, urinary 8-OHdG levels were sig...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - Category: Cytology Source Type: research