Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy

The term ‘inhibitory checkpoint’ refers to the broad spectrum of co-receptors expressed by T cells that negatively regulate T cell activation thus playing a crucial role in maintaining peripheral self-tolerance. Co-inhibitory receptor ligands are highly expressed by a variety of malignancies allowing evasion of anti-tumour immunity. Recent studies demonstrate that manipulation of these co-inhibitory pathways can remove the immunological brakes that impede endogenous immune responses against tumours.
Source: Molecular Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research