Allo-reactive T cells for the treatment of hematological malignancies

Several mechanisms can be responsible for control of hematological tumors by allo-reactive T cells. Following allogeneic stem cell transplantation (alloSCT) donor T cells recognizing genetic disparities presented on recipient cells and not on donor cells are main effectors of tumor control, but also of the detrimental graft versus host disease (GVHD). Since after transplantation normal hematopoiesis is of donor origin, any T cell response directed against polymorphic antigens expressed on hematopoietic recipient cells but not on donor cells will result in an anti-tumor response not affecting normal hematopoiesis.

Source: Molecular Oncology - October 23, 2015 Category: Cancer & Oncology Authors: J.H.F. Falkenburg, I. Jedema Tags: Review Source Type: research