The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2

Conclusions: We present evidence indicating that the laforin/malin complex is able to interact with and ubiquitinate both PKM1 and PKM2. This post-translational modification, although it does not affect the catalytic activity of PKM1, it impairs the nuclear localization of PKM2.
Source: BMC Biochemistry - Category: Biochemistry Authors: Source Type: research