Cancer Immunotherapy: Strategies for Personalization and Combinatorial Approaches

The results of recent clinical trials using novel immunotherapy strategies such as immune checkpoint blockade and adoptive T-cell therapy approaches including CAR T-cell therapy have clearly established immunotherapy as an important modality for the treatment of cancer besides the traditional approaches of surgery, radiotherapy, and chemotherapy or targeted therapy. However, to date immunotherapy has been shown to induce durable clinical benefit in only a fraction of the patients. The use of combination strategies is likely to increase the number of patients that might benefit from immunotherapy.

Source: Molecular Oncology - October 22, 2015 Category: Cancer & Oncology Authors: Vishwanath Sathyanarayanan, Sattva S. Neelapu Tags: Review Source Type: research