Deletion of the nuclear localization sequence and C-terminus of parathyroid hormone-related protein decreases osteogenesis and chondrogenesis but increases adipogenesis and myogenesis in murine bone marrow stromal cells

In conclusion, the nuclear localization sequence and C-terminus are pro-osteochondrogenic, anti-adipogenic, and anti-myogenic.

Source: Journal of Tissue Engineering - October 12, 2015 Category: Biotechnology Authors: Hildreth, B. E., Hernon, K. M., Dirksen, W. P., Leong, J., Supsavhad, W., Boyaka, P. N., Rosol, T. J., Toribio, R. E. Tags: Original Article Source Type: research